| Bioactivity | PI3Kα-IN-23 (Compound 9) is an inhibitor of PI3Ka H1047R[1]. |
| Invitro | PI3Kα-IN-23 抑制细胞中 pAKT 磷酸化的能力分别为15 μΜ(SKBR3)[1]。PI3Kα-IN-23 抑制细胞增殖的能力分别为 EC50=500 nM-2 μΜ (T-47D); 2 μΜ-15 μΜ (SKBR3)[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> PI3Kα-IN-23 相关抗体: |
| In Vivo | 在 PK-Mouse 中的药代动力学分析[1] Route |
| Formula | C28H27N3O3 |
| Molar Mass | 453.53 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. James F et al. Preparation of ((4-oxo-3,4-dihydroquinazolin-8-yl)methyl)amine derivatives as PI3K inhibitors for the treatment of cancer. World Intellectual Property Organization, WO2024064024 A1 2024-03-28 |