Pipemidic acid_product_DataBase

Bioactivity

Pipemidic acid , a derivative of Piromidic acid, is an antibacterial agent. Pipemidic acid inhibits DNA gyrase. Pipemidic acid is active against gram-negative bacteria including Pseudomonas aeruginosa as well as some gram-positive bacteria. Pipemidic acid can be used for the research of intestinal, urinary, and biliary tract infections[1][2].

Invitro

Pipemidic acid 是 DNA 促旋酶的抑制剂，DNA 促旋酶是一种催化 ATP 依赖性 DNA 负超螺旋的细菌酶[2]。

In Vivo

Pipemidic acid (50 mg/kg) 口服吸收良好，在小鼠、大鼠、犬、猴中血浆峰浓度范围为 4~12 μg/mL[3]。Pipemidic acid 在小鼠单次口服后的平均致死剂量超过 16000 mg/kg[3]。

Name

Pipemidic acid

CAS

51940-44-4

Formula

C14H17N5O3

Molar Mass

303.32

Appearance

Solid

Transport

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Reference

[1]. Iacovino R, et al. β-Cyclodextrin inclusion complex to improve physicochemical properties of pipemidic acid: characterization and bioactivity evaluation. Int J Mol Sci. 2013 Jun 25;14(7):13022-41. [2]. Aoyama H, et, al. Purification of Citrobacter freundii DNA gyrase and inhibition by quinolones. Antimicrob Agents Chemother. 1988 Jan;32(1):104-9. [3]. Shimizu M, et, al. Pipemidic acid: absorption, distribution, and excretion. Antimicrob Agents Chemother. 1975 Apr;7(4):441-6.

PeptideDB

Pipemidic acid

CAS: 51940-44-4 F: C14H17N5O3 W: 303.32