| Bioactivity | SPK-601 (LMV-601) is an inhibitor of the phosphatidylcholine-specific phospholipase C (PC-PLC). SPK-601 also can be used as an antimicrobial agent[1]. | ||||||||||||
| Target | PC-PLC | ||||||||||||
| Invitro | SPK-601 (72 hours; HPV-31 cells) displays a dose dependent inhibitory effect on cell growth (IC50 of 16 μg/mL), and inhibits HPV-31 specific RNA expression and DNA replication[2]. Cell Viability Assay[2] Cell Line: | ||||||||||||
| Name | SPK-601 | ||||||||||||
| CAS | 1096687-52-3 | ||||||||||||
| Formula | C11H15KOS2 | ||||||||||||
| Molar Mass | 266.46 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Walker K.Interscience Conference on Antimicrobial Agents and Chemotherapy - 50th Annual Meeting - Research on Promising New Agents: Part 1.IDrugs. 2010 Nov;13(11):743-5. [2]. E. Amtmann, et al. Inhibition of high risk HPV-31 in human cervical epithelial cells in vitro by the PC-PLC inhibitor LMV-601. ICID, March 2010, 14: e465. |