| Bioactivity | Pip6a is an arginine-rich cell-penetrating peptide. Pip6a has the ability to deliver associated cargoes across the plasma and endosomal membranes and is stable to serum proteolysis. Pip6a is composed of a hydrophobic core region flanked on each side by arginine-rich domains containing β-alanine and aminohexanoyl spacers. Pip6a-conjugated morpholino phosphorodiamidate oligomer (PMO) dramatically enhanced antisense oligonucleotide (ASO) delivery into striated muscles of myotonic dystrophy (DM1) mice[1]. |
| Sequence | Ac-Arg-{Ahx}-Arg-Arg-{b-Ala}-Arg-Arg-{Ahx}-Arg-Tyr-Gln-Phe-Leu-Ile-Arg-{Ahx}-Arg-{b-Ala}-Arg-{Ahx}-Arg-{b-Ala} |
| Shortening | Ac-R-{Ahx}-RR-{b-Ala}-RR-{Ahx}-RYQFLIR-{Ahx}-R-{b-Ala}-R-{Ahx}-R-{b-Ala} |
| Formula | C127H225N53O26 |
| Molar Mass | 2910.48 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Arnaud F Klein, et al. Peptide-conjugated oligonucleotides evoke long-lasting myotonic dystrophy correction in patient-derived cells and mice. J Clin Invest. 2019 Nov 1;129(11):4739-4744. |