Ilicicolin A_product_DataBase

Bioactivity	Ilicicolin A is a potent anticancer agent. Ilicicolin A induces apoptosis. Ilicicolin A inhibits cell growth and colony formation. Ilicicolin A shows antitumor activity. Ilicicolin A has the potential for the research of prostate cancer[1].
Invitro	Ilicicolin A (0, 2.5, 5, 10 µM; 48 h) 诱导 22Rv1、C4-2B 细胞凋亡[1]。Ilicicolin A (0, 2.5, 5, 10 µM) 以剂量依赖性方式抑制 22Rv1 细胞和 C4-2B 细胞的细胞生长和集落形成[1]。Ilicicolin A (0, 2.5, 5, 10 µM; 48 h) 降低 EZH2、AURKA、PLK1、FoxM1、Cyclin B2、AR、c-Myc、cyclin D1 的蛋白质表达[1]。Ilicicolin A (0, 2.5, 5, 10 µM; 48 h) 降低AR、ALK2、ALK3 的 mRNA 表达呈剂量依赖性[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> Ilicicolin A 相关抗体: Cell Viability Assay[1] Cell Line:
In Vivo	Ilicicolin A (10 mg/kg; i.p.; six times a week for 3 weeks) 可抑制小鼠的肿瘤生长[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model:
CAS	22581-06-2
Formula	C23H31ClO3
Molar Mass	390.94
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Guo L, et al. Ilicicolin A Exerts Antitumor Effect in Castration-Resistant Prostate Cancer Via Suppressing EZH2 Signaling Pathway. Front Pharmacol. 2021 Oct 27;12:723729.

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