| Bioactivity | Pinacidil is a potent activator of potassium channel. Pinacidil is an antihypertensive agent which hyperpolarises vascular smooth muscle by opening K+-channels. Pinacidil significantly improves the reperfusion function and cardiac compliance. Pinacidil has direct cardioprotective efficacy[1]. | ||||||||||||
| Target | potassium channel | ||||||||||||
| Name | Pinacidil | ||||||||||||
| CAS | 60560-33-0 | ||||||||||||
| Formula | C13H19N5 | ||||||||||||
| Molar Mass | 245.32 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
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| Reference | [1]. Grover GJ, et al. Anti-ischemic effects of the potassium channel activators pinacidil and cromakalim and the reversal of these effects with the potassium channel blocker glyburide. J Pharmacol Exp Ther. 1989;251(1):98-104. [2]. Hamilton TC, et al. Cromakalim, nicorandil and pinacidil: novel drugs which open potassium channels in smooth muscle. Gen Pharmacol. 1989;20(1):1-9. |