Pim-1 kinase inhibitor 9_product_DataBase

Bioactivity	Pim-1 kinase inhibitor 9 (compound 8b) is a selective inhibitor against Pim-1 kinase with IC50 value of 0.24 µM. Pim-1 kinase inhibitor 9 inhibits cell cycle of T47D at S phase. Pim-1 kinase inhibitor 9 reveals antitumor activity[1].
Invitro	Pim-1 kinase inhibitor 9 抑制乳腺癌细胞 T47D 的生长，IC50值为9.8 μM（48h）和 2.61 μM（96h）[1]。Pim-1 kinase inhibitor 9 抑制 Pim-1 kinase 和 Pim-2 kinase 的活性，IC50 值为 0.24 μM（Pim-1 kinase）和 10.53 μM（Pim-2 kinase）[1]。 0 --> Pim-1 kinase inhibitor 9 相关抗体: Cell Cytotoxicity Assay[1] Cell Line:
In Vivo	Pim-1 kinase inhibitors 9（1 mg/kg，每周一次，共三周，腹腔注射）通过促进 caspase-3 的表达和抑制 VEGF 的表达来抑制小鼠Ehrlich实体瘤的生长[1]。 Animal Model:
Name	Pim-1 kinase inhibitor 9
Formula	C36H24F2N4S2
Molar Mass	614.73
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Al-Sanea MM,et al., Design, synthesis and cytotoxic evaluation of novel bis-thiazole derivatives as preferential Pim1 kinase inhibitors with in vivo and in silico study. J Enzyme Inhib Med Chem. 2023 Dec;38(1):2166936.

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