| Bioactivity | Pim-1 kinase inhibitor 8 (compound 12) is a potent inhibitor of Pim-1 kinase with an IC50 of 14.3 nM. Pim-1 kinase inhibitor 8 has potent cytotoxicity against MCF-7 and HepG2 cells with IC50s of 0.5 and 5.27 μM, respectively. Pim-1 kinase inhibitor 8 can used in study breast cancer[1]. | ||||||||||||
| Name | Pim-1 kinase inhibitor 8 | ||||||||||||
| CAS | 916038-47-6 | ||||||||||||
| Formula | C14H17N3O3 | ||||||||||||
| Molar Mass | 275.30 | ||||||||||||
| Appearance | 固体 | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
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| Reference | [1]. Shaban SM, et al. Design and Synthesis of Novel Pyridine-Based Compounds as Potential PIM-1 Kinase Inhibitors, Apoptosis, and Autophagy Inducers Targeting MCF-7 Cell Lines: In Vitro and In Vivo Studies. ACS Omega. 2023 Nov 27;8(49):46922-46933. |
Pim-1 kinase inhibitor 8
CAS: 916038-47-6 F: C14H17N3O3 W: 275.30
Pim-1 kinase inhibitor 8 (compound 12) is a potent inhibitor of Pim-1 kinase with an IC50 of 14.3 nM. Pim-1 kinase inhib
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