| Bioactivity | Pilsicainide (SUN 1165 free acid) is a potent sodium channel blocker and potent class Ic antiarrhythmic agent[1][2]. |
| Invitro | Pilsicainide (SUN 1165 free acid; 10-200 μg/mL) decreases peak amplitude of the net inward current in a dose-dependent manner with an IC50 of 29.2 μg/mL in levo-thyroxine (T4)-treated rat atrial cells[1]. |
| In Vivo | Pilsicainide (SUN 1165 free acid; 2 mg/kg; i.v.; once) decreases the conduction velocity in T4-treated rat atrium by decreasing the Max dV/dt and net inward current[1]. Animal Model: |
| Name | Pilsicainide |
| CAS | 88069-67-4 |
| Formula | C17H24N2O |
| Molar Mass | 272.39 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Yamakawa M, et al. Effect of sodium channel blocker, pilsicainide hydrochloride, on net inward current of atrial myocytes in thyroid hormone toxicosis rats. Thyroid. 2005 Jul;15(7):653-9. [2]. Plosker GL. Pilsicainide. Drugs. 2010 Mar 5;70(4):455-67. |