| Bioactivity | APJ receptor agonist 1, a biphenyl acid derivative, is a potent APJ receptor (APJ-R) agonist (EC50s 0.093 and 0.12 nM for human and rat APJ-R, respectively). APJ receptor agonist 1 displays in vitro potency to apelin-13, the endogenous peptidic ligand for the APJ receptor. APJ receptor agonist 1 has the potential for the research of heart failure[1]. |
| Invitro | The S-atropisomer APJ receptor agonist 1 (compound 15a) is 200-fold more potent than the corresponding R-atropisomer.[1]. |
| In Vivo | APJ receptor agonist 1 (10-100 μg/min/kg; intravenous infusion) induces a 10% increase in CO with minimal impact on blood pressure (<5% transient blood pressure drop)[1]. Animal Model: |
| Name | APJ receptor agonist 1 |
| CAS | 2287153-38-0 |
| Formula | C31H26ClN3O3 |
| Molar Mass | 524.01 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Su S, Clarke A, et al. Biphenyl Acid Derivatives as APJ Receptor Agonists. J Med Chem. 2019;62(22):10456-10465. |
APJ receptor agonist 1
CAS: 2287153-38-0 F: C31H26ClN3O3 W: 524.01
APJ receptor agonist 1, a biphenyl acid derivative, is a potent APJ receptor (APJ-R) agonist (EC50s 0.093 and 0.12 nM fo
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