Phenylpyropene C_product_DataBase

Bioactivity	Phenylpyropene C (S14-95), a JAK/STAT pathway inhibitor, can inhibit IFN-γ mediated expression of the reporter gene (IC50=5.4~10.8 μM). Phenylpyropene C also is an inhibitor of acyl-CoA, with an IC50 of 16.0 μM[1][2].
Invitro	Phenylpyropene C (0.1-1000 μM) inhibits ACAT activity with the IC50 of 16.0 μM in a dose dependent fashion[1].Phenylpyropene C inhibits the IFN-γ mediated expression of the reporter gene with IC50s of 5.4 μM to approximately 10.8 μM[2].Phenylpyropene C inhibits the expression of the proinflammatory enzymes COX-2 and NOS II at 10.8 μM in LPS/IFN-γ stimulated J774 mouse macrophages[2].Phenylpyropene C inhibits the activation of the p38 MAP kinase, which is involved in the inducible expression of many proinflammatory genes[2].
Name	Phenylpyropene C
CAS	419532-92-6
Formula	C28H34O5
Molar Mass	450.57
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Rho MC, et, al. Phenylpyropene C, a new inhibitor of acyl-CoA: cholesterol acyltransferase produced by Penicillium griseofulvum F1959. J Antibiot (Tokyo). 2002 Feb;55(2):211-4. [2]. Erkel G, et, al. S14-95, a novel inhibitor of the JAK/STAT pathway from a Penicillium species. J Antibiot (Tokyo). 2003 Apr;56(4):337-43.

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