Anti-inflammatory agent 11_product_DataBase

Bioactivity	Anti-inflammatory agent 11 (compound 16) is a potent antimycobacterial and anti-inflammatory agent. Anti-inflammatory agent 11 inhibits Mtb H37Rv and M299 growth, with MIC50 (minimum inhibitory concentration 50%) of 1.3 and 6.9 μM, respectively. Anti-inflammatory agent 11 inhibits NO through the suppression of iNOS expression, and also inhibited the production of TNF-α and IL-1β. Anti-inflammatory agent 11 can be used for tuberculosis (TB) research[1].
Target	MIC50: 1.3 ± 1.1 μM (Mtb H37Rv), 6.9 ± 0.8 μM (Mtb M299); IC50: 7.4 ± 1.1 μM (NO)
Invitro	Anti-inflammatory agent 11 (compound 16) is active in the reduction of accumulated nitrite, with an IC50 of 64.8 ± 1.0 μM[1].
Name	Anti-inflammatory agent 11
CAS	63932-07-0
Formula	C14H14N4OS
Molar Mass	286.35
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Calixto SD, et al. Antimycobacterial and anti-inflammatory activities of thiourea derivatives focusing on treatment approaches for severe pulmonary tuberculosis. Bioorg Med Chem. 2022 Jan 1;53:116506.

PeptideDB