| Bioactivity | Phenacaine (Holocaine) is a local anesthetic. Phenacaine inhibits the specific calmodulin-dependent stimulation of erythrocyte Ca2+-ATPase and cyclic nucleotide phosphodiesterases from brain and heart[1][2]. |
| Invitro | Phenacaine inhibits the specific calmodulin-dependent stimulation of erythrocyte Ca2+-ATPase (EC 3.6.1.3) and cyclic nucleotide phosphodiesterase (EC 3.1.4.17) in brain and heart tissues[1].Phenacaine (1 μM-1 mM) depresses glucose-induced insulin secretion by pancreas[2]. |
| Name | Phenacaine |
| CAS | 101-93-9 |
| Formula | C18H22N2O2 |
| Molar Mass | 298.38 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. M Volpi, et al. Local anesthetics, mepacrine, and propranolol are antagonists of calmodulin. Proc Natl Acad Sci U S A. 1981 Feb;78(2):795-9. [2]. R Bressler, et al. Effect of local anesthetics on insulin secretion by pancreas pieces. Diabetes. 1971 Nov;20(11):721-8. |