| Bioactivity | BMS-986118 is a potent, orally active, and selective GPR40 agonist with an EC50 of 0.07 µM. BMS-986118 has dual insulinotropic and GLP-1 secretory effects, resulting in robust plasma glucose lowering effects in acute animal models[1]. |
| Target | IC50: 0.07 µM (GPR40) |
| Name | BMS-986118 |
| CAS | 1610562-74-7 |
| Formula | C25H28ClF3N4O4 |
| Molar Mass | 540.96 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Shi J, et al. Discovery of Potent and Orally Bioavailable Dihydropyrazole GPR40 Agonists. J Med Chem. 2018;61(3):681-694. |
BMS-986118
CAS: 1610562-74-7 F: C25H28ClF3N4O4 W: 540.96
BMS-986118 is a potent, orally active, and selective GPR40 agonist with an EC50 of 0.07 µM. BMS-986118 has dual insulin
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