| Bioactivity | Pertussis Toxin is a protein-based AB5-type exotoxin produced by the bacterium Bordetella pertussis, which causes whooping cough. Pertussis Toxin inhibits G protein-coupled receptor (GPR) signaling through Gi proteins[1][2][3]. |
| Invitro | Pertussis toxin is a secreted protein exotoxin and an important virulence factor produced exclusively by B. pertussis[1]. Pertussis toxin (PTX; 100 ng/ml; 12 h) completely suppresses the increase in G protein-coupled receptor kinase 2 (GRK2)-dependent migration in HeLa cells[2]. |
| Name | Pertussis Toxin |
| CAS | 70323-44-3 |
| Appearance | Solid |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Store at 4°C, do not freeze |
| Reference | [1]. Carbonetti NH, et al. Pertussis toxin and adenylate cyclase toxin: key virulence factors of Bordetella pertussis and cell biology tools. Future Microbiol. 2010 Mar;5(3):455-69. [2]. Petronila Penela, et al. G protein-coupled receptor kinase 2 positively regulates epithelial cell migration. EMBO J. 2008 Apr 23;27(8):1206-18. [3]. Nicholas H Carbonetti, et al. Contribution of pertussis toxin to the pathogenesis of pertussis disease. Pathog Dis. 2015 Nov;73(8):ftv073. |