| Bioactivity | Perphenazine is an orally active dopamine receptor and histamine-1 receptor antagonist, with Ki values of 0.56 nM (D2), 0.43 nM (D3), 6 nM (5-HT2A), respectively. Perphenazine also binds to Alpha-1A adrenergic receptor. Perphenazine inhibits cancer cell proliferation, and induces apoptosis. Perphenazine can be used in the research of mental disease, cancer, inflammation[1][3][5]. |
| Invitro | Perphenazine (40 μM, 48 h) inhibits cell viability, and induces cell apoptosis mediated by CTSD (Cathepsin D) in L02 cells[2].Perphenazine (30 μM, 24 h) induces intense lysosome vacuolation, impaired lysosomal membrane, and induces lysosomal membrane permeabilization (LMP), ultimately triggering lysosomal cell death in L02 cells[2].Perphenazine (10-40 μM, 24 h) inhibits autophagic flux in L02 cells[2].Perphenazine (1 µM, 24 h) decreases glioblastoma U-87 MG cell migration and invasion[4]. Cell Viability Assay[2] Cell Line: |
| Name | Perphenazine |
| CAS | 58-39-9 |
| Formula | C21H26ClN3OS |
| Molar Mass | 403.97 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | 4°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light) |
Perphenazine
CAS: 58-39-9 F: C21H26ClN3OS W: 403.97
Perphenazine is an orally active dopamine receptor and histamine-1 receptor antagonist, with Ki values of 0.56 nM (D2),
Data collection：peptidedb@qq.com
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