| Bioactivity | Penduletin is a flavone, that can be isolated from Brickelia pendula and Vitex negundo. Penduletin shows anticancer activity. Penduletin induces apoptosis in the cancer cells through ROS generation[1][2]. |
| Invitro | Penduletin（0-100 µg/mL，48 小时）对 HepG2 和 MCF-7 细胞系具有抗增殖活性，IC50 值分别为 25.8 和 6.4 µM[1]。Penduletin 可诱导 HepG2 中的 procaspase-3 裂解，以及 MCF-7 细胞系中的 procaspase-3 和 procaspase-8[1]。 |
| Name | Penduletin |
| CAS | 569-80-2 |
| Formula | C18H16O7 |
| Molar Mass | 344.32 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Flores S E, et al.The structure of pendulin and penduletin: a new flavonol glucoside isolated from brickelia pendula[J].Tetrahedron, 1958, 2(3-4):308-315. [2]. Vo GV, et al. In silico and in vitro studies on the anti-cancer activity of artemetin, vitexicarpin and penduletin compounds from Vitex negundo. Saudi Pharm J. 2022 Sep;30(9):1301-1314. |