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AMPK activator 11

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Bioactivity AMPK activator 11 is an AMP-activated protein kinase (AMPK) activator with nanomolelevel antiproliferation activities against several CRCs. AMPK activator 11 selectively inhibits the RKO xenograft growth along by activating AMPK and upregulating oxidative phosphorylation (OXPHOS) ( mitochondrial metabolism ) and can be used for anti-tumor and metabolic disease research[1].
Invitro AMPK activator 11 (Compound 18a) (0-30 μM;0-7 天) 抑制 CRC 细胞的生长和迁移,对其 IC50 值低于 1 μM[1]。AMPK activator 11 (0-0.1 μM;24 小时) 显著提高 RKO 细胞的全局耗氧率 (OCR) ,同时细胞外酸化率 (ECAR) 轻微变化。AMPK activator 11 上调 p-AMPK 和线粒体复合物 III 和 V 的表达,并且具有在 CRC 中选择性激活 OXPHOS 的能力[1]。 Cell Viability Assay[1] Cell Line:
In Vivo AMPK activator 11 (Compound 18a) (2.5 或 10 mg/kg 腹腔注射,持续 25 天) 选择性抑制 RKO 细胞体外异种肿瘤模型的肿瘤生长,且无毒性[1]>。 Animal Model:
Name AMPK activator 11
Formula C25H20N4O2
Molar Mass 408.45
Transport Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

Reference [1]. Xu YH, Design and Synthesis of Bouchardatine Derivatives as a Novel AMP-Activated Protein Kinase Activator for the Treatment of Colorectal Cancer. J Med Chem. 2023 Jun 8;66(11):7387-7404.

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