Pancreatic polypeptide_product_DataBase

Bioactivity	Pancreatic polypeptide is a peptide secreted by the endocrine PP cells of the pancreas that regulates pancreatic secretory activity and also affects hepatic glycogen stores and gastrointestinal secretion[1].
Invitro	Pancreatic polypeptid (PP) (0.1 μM, 48 h) 导致 mHippo E18 细胞的生长抑素分泌显着减少[1]。
In Vivo	Pancreatic polypeptid (PP) (1 μM, Hippocampal injection, 0.2 μL/min followed by 3 min) 可以刺激小鼠脑中含生长抑素细胞中神经元激活标记物 c-Fos 的表达，表明其可以激活小鼠海马体中含生长抑素的细胞[1]。
Name	Pancreatic polypeptide
CAS	59763-91-6
Sequence	Ala-Pro-Leu-Glu-Pro-Val-Tyr-Pro-Gly-Asp-Asn-Ala-Thr-Pro-Glu-Gln-Met-Ala-Gln-Tyr-Ala-Ala-Asp-Leu-Arg-Arg-Tyr-Ile-Asn-Met-Leu-Thr-Arg-Pro-Arg-Tyr-NH2
Shortening	APLEPVYPGDNATPEQMAQYAADLRRYINMLTRPRY-NH2
Formula	C185H286N52O55S2
Molar Mass	4182.70
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Wook Kim, et al. Pancreatic polypeptide inhibits somatostatin secretion. FEBS Lett. 2014 Aug 25;588(17):3233-9.

PeptideDB