| Bioactivity | GSK9027, as a non-steroidal glucocorticoid receptor (GR) agonist, behaves as a partial agonist on the 2×glucocorticoid response element (GRE) reporter system, and achieves intrinsic activities relative to dexamethasone[1][2]. |
| Target | GR |
| Invitro | GSK9027 demonstrates reduced 2×GRE reporter activation and is partial agonists[2]. |
| Name | GSK9027 |
| CAS | 1229096-88-1 |
| Formula | C27H19F4N3O2S |
| Molar Mass | 525.52 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Rider CF, et al. Cytokine-Induced Loss of Glucocorticoid Function: Effect of Kinase Inhibitors, Long-Acting β2-Adrenoceptor Agonist and Glucocorticoid Receptor Ligands. PLoS ONE. 2015; 10(1): e0116773. [2]. Rider, C. F., et al. TNF±-Induced Glucocorticoid Resistance: Inhibition Of Inflammatory Signalling And The Effect On Full And Partial GR Agonists. 2012 |
GSK9027
CAS: 1229096-88-1 F: C27H19F4N3O2S W: 525.52
GSK9027, as a non-steroidal glucocorticoid receptor (GR) agonist, behaves as a partial agonist on the 2×glucocorticoid
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