| Bioactivity | PYRIB-SO 2 is a potent antimitotic agent. PYRIB-SO 2 shows antiproliferative activity and induces cell cycle arrest at G2/M phase. PYRIB-SO 2 reduces and disruptes microtubule structures. PYRIB-SO 2 binds to the colchicine-binding site (C-BS) of α, β-tubulin[1]. |
| Invitro | PYRIB-SO 2 (150 nM; 24 h) 诱导细胞周期停滞在 G2/M 期[1]。PYRIB-SO 2 (138 Nm; 24 h) 可减少并破坏 MCF7 细胞中的微管结构[1]。PYRIB-SO 2 (5, 50 µM) 减少 EBI:β-微管蛋白加合物的形成[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> PYRIB-SO 2 相关抗体: Cell Proliferation Assay[1] Cell Line: |
| Formula | C14H12ClN3O4S |
| Molar Mass | 353.78 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Ouellette V, et al. Modification of the phenyl ring B of phenyl 4-(2-oxoimidazolidin-1-yl)benzenesulfonates by pyridinyl moiety leads to novel antimitotics targeting the colchicine-binding site. Bioorg Med Chem Lett. 2024 Jun 1;105:129745. |