| Bioactivity | PW507 is a potent, brain-penetrant and selective sigma 1 receptor (S1R) antagonist with a Ki of 7.5 nM for human S1R. PW507 displays a low binding affinity to S2R and hERG. PW507 can be used for the study of painful diabetic neuropathy (PDN)[1]. |
| Invitro | PW507 与人类 S1R 晶体结构的正构位点结合，并与受体发生强烈相互作用[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> PW507 相关抗体: |
| In Vivo | PW507（20 mg/kg；腹腔注射；每日两次；持续 14 天）在缓解机械性痛觉过敏方面表现出显著疗效[1]。PW507 在 SD 大鼠中的药代动力学特性研究[1]。1.19 plasma PK |
| CAS | 2573850-59-4 |
| Formula | C18H27ClN4 |
| Molar Mass | 334.89 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Youyi Peng, et al. Preclinical Evaluation of Sigma 1 Receptor Antagonists as a Novel Treatment for Painful Diabetic Neuropathy. ACS Pharmacol. Transl. Sci. July 18, 2024. |