CDK7-IN-30_product_DataBase

Bioactivity	CDK7-IN-30 (Compound 22) is a CDK7 inhibitor (IC50 = 7.21 nM) that effectively inhibits the phosphorylation of RNA Polymerase II and CDK2. CDK7-IN-30 CDK7-IN-30 can induce cell apoptosis and has anti-cancer activity and can be used in cancer research[1].
Invitro	CDK7-IN-30 (Compound 22) 对癌细胞表现出强效的抗增殖作用，IC50 值分别为 288.0 nM (RS4;11)、174.6 nM (MM.1S)、37.5 nM (Mino) 和168.7 nM (Jeko-1)。同时，对正常血细胞 PBMCs 的抑制作用较弱，IC50 为 757.9 nM[1]。CDK7-IN-30 (50-500 nM; 24 h) 在 MV4-11 细胞中导致细胞周期停滞在 G1/S 期并 (100-1000 nM; 48 h) 促进细胞凋亡[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> CDK7-IN-30 相关抗体:
CAS	3040999-70-7
Formula	C21H28ClN5O3S
Molar Mass	466.00
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Zhang H, et al. Design, Synthesis, and Biological Evaluation of 2, 4-Diaminopyrimidine Derivatives as Potent CDK7 Inhibitors[J]. ACS Medicinal Chemistry Letters, 2024.

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