PTPN2/1-IN-1

CAS: 2407610-46-0 F: C13H11FN2O5S W: 326.30

PTPN2/1-IN-1 (Compound 124) is an orally active PTPN1 and PTPN2 inhibitor with IC50s of 4.4 nM and 1-10 nM against PTPN2

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Bioactivity	PTPN2/1-IN-1 (Compound 124) is an orally active PTPN1 and PTPN2 inhibitor with IC50s of 4.4 nM and 1-10 nM against PTPN2 and PTP1B, respectively[1].
Target	IC50: 4.4 nM (PTPN2), 1-10 nM (PTP1B)
Invitro	PTPN2/1-IN-1 (Compound 124; 5 days) 抑制 IFNγ (0.5 ng/mL) 诱导的 B16F10 细胞生长，33 μM 的生长抑制率为 60-90%[1]。
In Vivo	PTPN2/1-IN-1 (Compound 124; 300 mg/kg; oral; BID for 21 days) 在小鼠中具有抗肿瘤活性[1]。 Animal Model:
Name	PTPN2/1-IN-1
CAS	2407610-46-0
Formula	C13H11FN2O5S
Molar Mass	326.30
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Elliot FARNEY, et al. Protein tyrosine phosphatase inhibitors and methods of use thereof. Patent WO2019246513A1.

(±)-Coniine hydrochloride