| Bioactivity | PTP1B-IN-27 (Compound 7i) is an inhibitor of protein tyrosine phosphatase 1-B (PTP‐1B)(IC50=8.2 µM). PTP1B-IN-27 also inhibits α-Glucosidase (IC50=120 µM) and shows competitive inhibition (Ki=118 µM)[1]. |
| Invitro | PTP1B-IN-27 (50 µM; 48 h) 对人类真皮成纤维细胞 (HDF) 显示出非细胞毒性[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> PTP1B-IN-27 相关抗体: |
| Formula | C26H24FN7O2S |
| Molar Mass | 517.58 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Ansariashlaghi S, et al. New phenylthiosemicarbazide-phenoxy-1,2,3-triazole-N-phenylacetamides as dual inhibitors against α-glucosidase and PTP-1B for the treatment of type 2 diabetes. Arch Pharm (Weinheim). 2024 Apr 9:e2300517. |