PTP Inhibitor IV_product_DataBase

Bioactivity	PTP Inhibitor IV is a protein tyrosine phosphatase (PTP) inhibitor that competitively inhibits DUSP14 phosphatase activity with an 50 of 5.21 μM[1]. PTP Inhibitor IV inhibits SHP-2, PTP1B, PTP-ε, PTP Meg-2, PTP-σ, PTP-β, and PTP-μ with 50s of 1.8 μM, 2.5 μM, 8.4 μM, 13 μM, 20 μM, 6.4 μM, and 6.7 μM, respectively[2].
Target	IC50: 1.8 μM (SHP-2), 2.5 μM (PTP1B), 8.4 μM (PTP-ε), 13 μM (PTP Meg-2), 20 μM (PTP-σ), 6.4 μM (PTP-β), and 6.7 μM (PTP-μ); 5.21 μM (DUSP14)
Invitro	PTP Inhibitor IV 通过结合在催化位点下调 DUSP14 的催化活性[1]。PTP Inhibitor IV（0-100 μM；3 小时）有效且特异性地抑制 DUSP14 介导的 JNK 去磷酸化[1]。 Western Blot Analysis[1] Cell Line:
Name	PTP Inhibitor IV
CAS	329317-98-8
Formula	C26H26F6N2O4S2
Molar Mass	608.62
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Jae Eun Park, et al. PTP inhibitor IV protects JNK kinase activity by inhibiting dual-specificity phosphatase 14 (DUSP14). Biochem Biophys Res Commun. 2009 Oct 2;387(4):795-9. [2]. Ping Huang, et al. Structure-based design and discovery of novel inhibitors of protein tyrosine phosphatases. Bioorg Med Chem. 2003 Apr 17;11(8):1835-49.

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