Flt-3 Inhibitor III_product_DataBase

Bioactivity	Flt-3 Inhibitor III is a potent and selective FLT3 kinase inhibitor with an 50 of 50 nM. Flt-3 Inhibitor III shows less active against other kinases. Flt-3 Inhibitor III has anticancer effects[1].
Target	IC50: 50 nM (FLT3 kinase)
Invitro	Flt-3 Inhibitor III（化合物 4）也抑制 c-Kit、KDR、c-Abl、CDK1、c-Src 和 Tie-2，IC50 值分别为 0.26 µM、0.91 µM、1.2 µM、2.1 µM、2.8 µM 和 8.0 µM[1]。Flt-3 Inhibitor III（化合物 4）阻断 BaF3-ITD、BaF3-D835/Y 和 MV4:11 细胞的增殖，IC50 值分别为 0.24 µM、0.76 µM 和 0.052 µM[1] 。
Name	Flt-3 Inhibitor III
CAS	852045-46-6
Formula	C21H23N3OS
Molar Mass	365.49
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Pascal Furet, et al. Aromatic interactions with phenylalanine 691 and cysteine 828: a concept for FMS-like tyrosine kinase-3 inhibition. Application to the discovery of a new class of potential antileukemia agents. J Med Chem. 2006 Jul 27;49(15):4451-4.

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