| Bioactivity | PTG-0861 is a selective histone deacetylase 6 (HDAC6) inhibitor with the IC50 value of 5.92 nM. PTG-0861 induces apoptosis and can be used in the study of acute myeloid leukemia, multiple myeloma and other hematological cancers[1]. |
| Invitro | PTG-0861 (compound 54) (0.1-5 μM, 6 hours) stimulates the expression of acetylated a-tubulin and has inhibitory activity against HDAC6 with the IC50 value of 0.59 μM[1].PTG-0861 (compound 54) (0-4 μM, 18 hours) can induce apoptosis in a dose-dependent manner and has some cytotoxic effect[1]. Western Blot Analysis[1] Cell Line: |
| Name | PTG-0861 |
| CAS | 2494082-34-5 |
| Formula | C15H9F5N2O3 |
| Molar Mass | 360.24 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
PTG-0861
CAS: 2494082-34-5 F: C15H9F5N2O3 W: 360.24
PTG-0861 is a selective histone deacetylase 6 (HDAC6) inhibitor with the IC50 value of 5.92 nM. PTG-0861 induces apoptos
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