| Bioactivity | PD173952 is a tyrosine kinases inhibitor with IC50s of 0.3, 1.7 and 6.6 nM against Lyn, Abl and Csk, respectively. PD173952 is also a potent Myt1 kinase inhibitor with a Ki of 8.1 nM. PD173952 induces apoptosis[1][2]. |
| Invitro | PD173952 (0-1000 nM; 12 h) 以浓度依赖方式抑制 K562 细胞中 p210Bcr-Abl 和 CrkL 的酪氨酸磷酸化[1]。PD173952 (0.5 μM; 1-4 days) 抑制 K562 细胞活力[1]。PD173952 (0.5 μM; 24 and 48 h) 诱导 K562 和 MEG-01 细胞凋亡[1]。 Western Blot Analysis[1] Cell Line: |
| Name | PD173952 |
| CAS | 305820-75-1 |
| Formula | C24H21Cl2N5O2 |
| Molar Mass | 482.36 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
PD173952
CAS: 305820-75-1 F: C24H21Cl2N5O2 W: 482.36
PD173952 is a tyrosine kinases inhibitor with IC50s of 0.3, 1.7 and 6.6 nM against Lyn, Abl and Csk, respectively. PD173
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