| Bioactivity | PSI (Proteasome Inhibitor 1) is a potent proteasome inhibitor. PSI inhibits the proliferation of primary effusion lymphoma (PEL) cells. PSI has the potential for the research of Kaposi’s sarcoma-associated herpesvirus (KSHV) infection and KSHV-associated lymphomas[1]. |
| Invitro | PSI (24 h) inhibits the proliferation of primary effusion lymphoma (PEL) cells at low nanomolar concentrations (CC50s of 205, 190, 22.0, 53.0 nM FOR BJAB, Ramos, BC3, BCBL1 cells, respectively)[1].PSI (50 nM; 6 h) increases caspase-3/7 activity by 8-fold compared with control[1].PSI (50 nM; 6 h) decreases the transcriptional activity of NF-κB by 52%[1].PSI (1, 5 nM; 3 days) inhibits the growth of BC3 cells at a high concentration (5 nM)[1]. Cell Cytotoxicity Assay[1] Cell Line: |
| Name | PSI |
| CAS | 158442-41-2 |
| Formula | C32H50N4O8 |
| Molar Mass | 618.76 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | -20°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) |