| Bioactivity | PS432 is a PKC inhibitor with IC50s of 16.9 μM (PKCι) and 18.5 μM (PKCζ), respectively. PS432 effectively inhibits the proliferation of non-small cell lung cancer cells (NSCLCs) and tumor growth in mouse xenograft models[1]. |
| Invitro | PS432 (25 μM; 24 h) 抑制癌细胞增殖，例如抑制 A549 和 A427 的 IC50 为 14.8 μM 和 10.4 μM[1]。PS432 (50 μM; 12, 24, 36 h) 将 A549 肺癌细胞的细胞周期阻滞在 G0/G1 期[1]。 |
| In Vivo | PS432 (2.5 mg/kg; 腹腔注射; 每天 1 次, 共 14 天) 在肺癌异种移植模型中抑制肿瘤生长[1]。 |
| Name | PS432 |
| CAS | 2083630-26-4 |
| Formula | C25H19ClN2O5S |
| Molar Mass | 494.95 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Arencibia JM, et al. An Allosteric Inhibitor Scaffold Targeting the PIF-Pocket of Atypical Protein Kinase C Isoforms. ACS Chem Biol. 2017 Feb 17;12(2):564-573. |