GPX4-IN-2

CAS: 2485005-22-7 F: C30H40N2O W: 444.65

GPX4-IN-2 is a potent GPX4 inhibitor. GPX4 shows antiproliferative activity. GPX4-IN-2 has the potential for the researc

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Bioactivity	GPX4-IN-2 is a potent GPX4 inhibitor. GPX4 shows antiproliferative activity. GPX4-IN-2 has the potential for the research of cancer[1].
Target	GPX4
Invitro	GPX4-IN-2 (compound 28) (0.0005-10 mM; 24 h) 显示出抗增殖活性，对于 786-O、SJSA-1、A431 细胞的 IC50 值分别为 0.004、0.016、2.9 µM[1]。 Cell Proliferation Assay[1] Cell Line:
In Vivo	GPX4-IN-2 (5 mg/kg for mouse, 2 mg/kg for rats; i.v.) 在小鼠和大鼠中显示出良好的药代动力学特征[1]。 Animal Model:
Name	GPX4-IN-2
CAS	2485005-22-7
Formula	C30H40N2O
Molar Mass	444.65
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Chun Jiang, et al. Compounds with ferroptosis inducing activity and methods of their use. WO2020176757A1.

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