| Bioactivity | PROTAC TBL1X degrader-1 (Compound TD11) is a PROTAC degrader for Transducin β-like protein 1 X-linked (TBL1X), and exhibits cytotoxicity in lymphoma cell Riva, Pfeiffer and Granta-519 with IC50 of 0.795, 0.397 and 0.522 μM, respectively. (Pink: ligand for target protein: TBL1X ligand 1 (HY-168191); Black: linker (HY-168193); Blue: ligand for E3 ligase: Thalidomide 4-fluoride (HY-41547))[1] |
| Formula | C49H60N8O11S2 |
| Molar Mass | 1001.18 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Yang R, et al., Design, Synthesis, and Biological Evaluation of Selective TBL1X Degraders. ACS Med Chem Lett. 2024 Oct 1;15(10):1699-1707. |
PROTAC TBL1X degrader-1
CAS: F: C49H60N8O11S2 W: 1001.18
PROTAC TBL1X degrader-1 (Compound TD11) is a PROTAC degrader for Transducin β-like protein 1 X-linked (TBL1X), and exhi
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