PROTAC PIPIB degrader 1_product_DataBase

Bioactivity	PROTAC PIPIB degrader 1 (compound 75) is a CRBN-based PTP1B PROTAC degrader, with DC50 values of 0.2 μM (48 h) and 0.05 μM (72 h) (Red: PTP1B ligand Oleanolic acid (HY-N0156); Black: linker; Blue: CRBN ligand)[1].
In Vivo	PROTAC PIPIB degrader 1 (compound 75) 在口服葡萄糖耐量试验中将血糖 AUC0–2h 降低至29%，并在 HepG2 细胞中激活 IRS-1/PI3K/Akt 信号通路，显示出长期抗糖尿病的良好前景[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Formula	C61H92N4O11
Molar Mass	1057.40
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Zunhua Yang, et al. Discovery of Selective Proteolysis-Targeting Chimera Degraders Targeting PTP1B as Long-Term Hypoglycemic Agents. J Med Chem. 2024 May 9;67(9):7569-7584.

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