| Bioactivity | PROTAC K-Ras degrader-2 (compound 48) is a pan-KRAS-mutant PROTAC degrader with an IC50 of ≤200 nM for KRAS G12V/RAF1. PROTAC K-Ras degrader-2 degrades SW620 KRAS G12D with a DC50 of ≤200 nM. PROTAC K-Ras degrader-2 inhibits cell growth of SW620 3D cell with an IC50 of ≤20 nM. (Pink: KRAS inhibitor-30 (HY-164366))[1]. |
| CAS | 3043670-74-9 |
| Formula | C52H60F4N8O5 |
| Molar Mass | 953.08 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Robert Luo, et al. Glutarimide-containing pan-kras-mutant degrader compounds and uses thereof. WO2024118966A1. |
PROTAC K-Ras Degrader-2
CAS: 3043670-74-9 F: C52H60F4N8O5 W: 953.08
PROTAC K-Ras degrader-2 (compound 48) is a pan-KRAS-mutant PROTAC degrader with an IC50 of ≤200 nM for KRAS G12V/RAF1.
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This product is for research use only, not for human use. We do not sell to patients.