| Bioactivity | PROTAC IRAK4 degrader-11 (compound 15) is PROTAC based on Cereblon ligand, and induces the degradation of IRAK4 with maximum degradation of 96.25% and the DC50 of 2.29 nM in HEK293 cells(Sturcture Note:(Blue: Cereblon ligand (HY-14658), Black: linker；Pink: IRAK4 inhibitor)[1]. |
| Formula | C41H41F3N8O6 |
| Molar Mass | 798.81 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Zhang Xuejun, et al. Imidazopyridines as IRAK4 degradants and uses thereof. CN117777126A. 2024-03-29. |
PROTAC IRAK4 degrader-11
CAS: F: C41H41F3N8O6 W: 798.81
PROTAC IRAK4 degrader-11 (compound 15) is PROTAC based on Cereblon ligand, and induces the degradation of IRAK4 with max
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