| Bioactivity | PROTAC HDAC6 degrader (Compound A6) is a potent and selective PROTAC HDAC6 degrader with a DC50 of 3.5 nM. PROTAC HDAC6 degrader shows promising antiproliferative activity via inducing apoptosis in myeloid leukemia cell lines[1]. |
| Invitro | PROTAC HDAC6 degrader (Compound A6) (0.1-10 μM; 6 h) does not degrade HDAC1 but displays inhibitory activity toward HDAC1. PROTAC HDAC6 degrader demonstrates potent HDAC6 degradation as well as hyperacetylation of α-tubulin in U266 and HL-60 cells, confirming that the activity is not restricted to leukemia cell lines[1].PROTAC HDAC6 degrader (0.5-50 μM) inhibits leukemia cells viability with log IC50 values of 1.2-1.7 μM[1].PROTAC HDAC6 degrader (8-24 μM; 48 h) induces MOLM13 cell apoptosis and arrests cell cycle at sub-G1 phase[1]. Western Blot Analysis[1] Cell Line: |
| Name | PROTAC HDAC6 degrader 1 |
| CAS | 2785404-76-2 |
| Formula | C37H46N6O10 |
| Molar Mass | 734.80 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
PROTAC HDAC6 degrader 1
CAS: 2785404-76-2 F: C37H46N6O10 W: 734.80
PROTAC HDAC6 degrader (Compound A6) is a potent and selective PROTAC HDAC6 degrader with a DC50 of 3.5 nM. PROTAC HDAC6
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