PROTAC FLT3/CDK9 degrader-1_product_DataBase

Bioactivity	PROTAC FLT3/CDK9 degrader-1 is a potent FLT3 and CDK9 dual PROTAC degrader. PROTAC FLT3/CDK9 degrader-1 induces apoptosis and effective degradation of target proteins FLT3 and CDK9. PROTAC FLT3/CDK9 degrader-1 has the potential for the research of FLT3-ITD mutated AML[1].
Invitro	PROTAC FLT3/CDK9 degrader-1 (compound PROTAC 13) (0.004, 0.02, 0.1, 0.5, 2.5 µM; 16 h) 降低 p-FLT3 Y589/591、p-STAT5 Y694、p-ERK1/2 T202/Y204 的表达,并以剂量依赖性方式诱导 MV4-11 细胞凋亡[1]。在 MV4-11 细胞中用 MG132 (HY-13259) (0.2 µM) 预处理 90 分钟后，PROTAC FLT3/CDK9 degrader-1 (0, 0.1, 0.5 µM; 16 h) 的蛋白降解能力减弱[1]。 Cell Proliferation Assay[1] Cell Line:
Name	PROTAC FLT3/CDK9 degrader-1
Formula	C48H62N12O7
Molar Mass	919.08
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.

PeptideDB