| Bioactivity | PROTAC EZH2 Degrader-3 (compound ZJ-20) is a EZH2 degrader. PROTAC EZH2 Degrader-3 (5 μM, 24 h) not only potently inhibits the expression of EZH2 protein, but also had a strong inhibits effect on the expression levels of other subunits of PRC2 as well as H3k27me3 protein. PROTAC EZH2 Degrader-3 shows anti-proliferative activity and blocks the cell cycle in the G0-G1 phase and induces cell apoptosis((Blue: cereblon ligand Pomalidomide (HY-10984), Black: linker HY-W361751；Pink: EZH2 inhibitor Tazemetostat (HY-13803))[1]. |
| Formula | C56H68N8O8 |
| Molar Mass | 981.19 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Fu M, et al. Chemically induced degradation of PRC2 complex by EZH2-Targeted PROTACs via a Ubiquitin-Proteasome pathway. Bioorg Med Chem Lett. 2024;113:129968. |
PROTAC EZH2 Degrader-3
CAS: F: C56H68N8O8 W: 981.19
PROTAC EZH2 Degrader-3 (compound ZJ-20) is a EZH2 degrader. PROTAC EZH2 Degrader-3 (5 μM, 24 h) not only potently inhib
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