| Bioactivity | PROTAC CDK9 degrader-5 is a PROTAC targeting to CDK9 sepcifically. PROTAC CDK9 degrader-5 mediates CDK9 degradation via the proteasome. PROTAC CDK9 degrader-5 degrades CDK9 with DC50s of 0.10 μM and 0.14 μM for the CDK942 and CDK955 isoforms, respectively[1]. |
| Invitro | PROTAC CDK9 degrader-5 (compound 15e) (1 μM；6 小时) 降低 MCL2 的蛋白质水平，并竞争性降解 MV411 细胞中的 CDK9[1]。PROTAC CDK9 degrader-5 (1 μM；1-6 小时) 时间依赖性地降低 MCL2 和 CDK9 的蛋白质水平，并保持 24 小时抑制[1]。 Western Blot Analysis[1] Cell Line: |
| Name | PROTAC CDK9 degrader-5 |
| Formula | C42H48Cl2N8O9 |
| Molar Mass | 879.78 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Tokarski RJ 2nd, et al. Bifunctional degraders of cyclin dependent kinase 9 (CDK9): Probing the relationship between linker length, properties, and selective protein degradation. Eur J Med Chem. 2023 Jun 5;254:115342. |
PROTAC CDK9 degrader-5
CAS: F: C42H48Cl2N8O9 W: 879.78
PROTAC CDK9 degrader-5 is a PROTAC targeting to CDK9 sepcifically. PROTAC CDK9 degrader-5 mediates CDK9 degradation via
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