| Bioactivity | PROTAC BRD4 Degrader-17 (compound 13i) is a potent PROTAC BRD4 Degrader, with IC50 values of 29.54 nM (BRD4 (BD1)) and 3.82 nM (BRD4 (BD2)). PROTAC BRD4 Degrader-17 significantly attenuates G2/M progression associated Cyclin B1 expression. PROTAC BRD4 Degrader-17 significantly induces apoptosis in MV-4-11 cells[1]. |
| Invitro | PROTAC BRD4 Degrader-17 (compound 13i) (100 nM，4-24 h) 在MV-4-11细胞中 4 h以 100 nM 的浓度显着诱导 BRD4 L 和 BRD4 S 降解，然后像 dBET6 一样在 24 h 恢复 BRD4 S[1]。 |
| Name | PROTAC BRD4 Degrader-17 |
| CAS | 2585561-49-3 |
| Formula | C49H47N7O9 |
| Molar Mass | 877.94 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Chen J, et al. Adjusted degradation of BRD4 S and BRD4 L based on fine structural modifications of the pyrrolopyridone scaffold. Eur J Med Chem. 2022 Jun 5;236:114259. |
PROTAC BRD4 Degrader-17
CAS: 2585561-49-3 F: C49H47N7O9 W: 877.94
PROTAC BRD4 Degrader-17 (compound 13i) is a potent PROTAC BRD4 Degrader, with IC50 values of 29.54 nM (BRD4 (BD1)) and 3
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