PRMT5-IN-41_product_DataBase

Bioactivity	PRMT5-IN-41 (compound 130) is a potent and orally active PRMT5 inhibitor. PRMT5-IN-41 inhibits hERG ion channel with IC50 value of 1.36 µM[1].
Invitro	PRMT5-IN-41 (compound 130) (0-10000 nM) 显示出抗增殖活性，对 HCT116 MTAP(-/-)、HCT116 WT 细胞的 IC50 值分别为 5.8、1291.6 µM[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> PRMT5-IN-41 相关抗体:
In Vivo	PRMT5-IN-41 (3 mg/kg for i.v.; 10 mg/kg for p.o.) 在 ICR 小鼠中的口服生物利用度为 77.5%，静脉注射和口服的 T1/2 值分别为 4.5、3.34 小时[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only.
CAS	3034034-32-4
Formula	C22H16F5N5O2
Molar Mass	477.39
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Bing Yao, et al. Novel prmt5 inhibitor and use thereof. WO2024067433A1.

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