| Bioactivity | 2G-HaloAUTAC (Compound tt44) is a second-generation autophagy-targeting chimera (2G-HaloAUTAC) that improves the activity of AUTACs by replacing the L-Cysteine (L-Cys) linker with other structures. 2G-HaloAUTAC exhibits degradation activity against EGFP-HaloTag protein through an autophagic mechanism[1]. |
| CAS | 2241668-58-4 |
| Formula | C31H43ClFN7O6 |
| Molar Mass | 664.17 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Takahashi D, et al., Second-Generation AUTACs for Targeted Autophagic Degradation. J Med Chem. 2023 Sep 14;66(17):12342-12372. |
2G-HaloAUTAC
CAS: 2241668-58-4 F: C31H43ClFN7O6 W: 664.17
2G-HaloAUTAC (Compound tt44) is a second-generation autophagy-targeting chimera(2G-HaloAUTAC) that improves the activity
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