PRL 3195_product_DataBase

Bioactivity	PRL 3195 is a somatostatin receptor antagonist with Kis of 6, 17, 66, 1000 and 1000 nM for human somatostatin receptors (sst5, sst2, sst3, sst1 and sst4, respectively)[1].
Invitro	PRL 3195 抑制人尿紧素 II (human urotensin II) 诱导的大鼠主动脉相位振荡，ED50 为 24 nM[1]。
Name	PRL 3195
CAS	341519-04-8
Sequence	{Phe<4Cl>}-{d-Cys}-{β-Ala<3-Py>}-{d-Trp}-{Lys<N2-Me>}-Thr-Cys-{2-Nal}-NH2 (Disulfide bridge:Cys2-Cys7)
Shortening	{F<4Cl>}-{d-C}-{β-A<3-Py>}-{d-W}-{K<N2-Me>}-TC-{2-Nal}-NH2 (Disulfide bridge:Cys2-Cys7)
Formula	C58H69ClN12O9S2
Molar Mass	1177.83
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Rossowski WJ, et al. Human urotensin II-induced aorta ring contractions are mediated by protein kinase C, tyrosine kinases and Rho-kinase: inhibition by somatostatin receptor antagonists. Eur J Pharmacol. 2002 Mar 8;438(3):159-70.

PeptideDB