IKKγ NBD Inhibitory Peptide_product_DataBase

Bioactivity	IKKγ NBD Inhibitory Peptide is a highly specific inhibitor NF-κB inhibitor. IKKγ NBD Inhibitory Peptide acts by disrupting the interaction between IKKγ/NEMO-binding domain (NBD) with IKKα and IKKβ, thus blocking TNF-α-induced NF-kB activation. IKKγ NBD Inhibitory Peptide could significantly suppresses inflammation and ameliorate the cerebral ischemia-induced neurological deficits[1][2][3].
Invitro	在一个典型途径中，NF-κB 的激活依赖于 IKK 复合体的活性，该复合体由三个亚基 (IKKκ、IKKβ 和 IKKγ/NEMO) 组成，因此，KKγ NBD 抑制肽抑制 TNF-α 诱导的 NF- kb激活[2]。IKKγ NBD 抑制肽 (10 μM; 90 min) 能够阻碍 Doxorubicin (HY-15142A) 诱导 (15 μM;4 h) 的 BT-474 细胞中 p65 磷酸化[2]。IKKγ NBD 抑制肽 (10 μM; 48 h) 对BT-474细胞活力有轻微抑制作用，而对 Doxorubicin 的效力有增强作用[2]。
In Vivo	IKKγ NBD 抑制肽 (40 μg/4 μL;ICV; 单剂量; 于 MCAO 诱导前 2 h) 在大鼠模型脑中动脉闭塞 (MCAO) 模型中显示出神经保护作用，减少 DNA 碎片化，其机制可能与减少缺血损伤后的炎症有关[3]。 Animal Model:
Name	IKKγ NBD Inhibitory Peptide
CAS	372146-18-4
Shortening	DRQIKIWFQNRRMKWKKTALDWSWLQTE
Formula	C170H259N49O42S1
Molar Mass	3693.30
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Zhao J, et al. Development of novel NEMO-binding domain mimetics for inhibiting IKK/NF-κB activation. PLoS Biol. 2018 Jun 11;16(6):e2004663. [2]. Tapia MA, et al. Inhibition of the canonical IKK/NF kappa B pathway sensitizes human cancer cells to doxorubicin. Cell Cycle. 2007 Sep 15;6(18):2284-92. [3]. Desai A, et al. Neuroprotective potential of the NF-κB inhibitor peptide IKK-NBD in cerebral ischemia-reperfusion injury. Neurochem Int. 2010 Dec;57(8):876-83.

PeptideDB

IKKγ NBD Inhibitory Peptide

CAS: 372146-18-4 F: C170H259N49O42S1 W: 3693.30