PPARδ agonist 10_product_DataBase

Bioactivity	PPARδ agonist 10 (compound 7) is an orally active, selective, and partial agonist of PPARδ, with EC50 values of 0.053 μM and 0.30 µM for hPPARδ(LBD)-GAL4 and mPPARδ, respectively. PPARδ agonist 10 is a partial PPARδ agonist in transactivation assay but a full agonist on free fatty acids (FFA) oxidation in muscle cells both in vitro and in vivo. PPARδ agonist 10 can be used for dyslipidemia research[1].
Invitro	PPARδ agonist 10 (compound 7) 可增加大鼠 L6 肌细胞中的脂肪酸氧化，EC50 为 30 nM[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> PPARδ agonist 10 相关抗体:
In Vivo	PPARδ agonist 10 (compound 7) 以剂量依赖性方式改变血浆脂质参数，以减少动脉粥样硬化[1]。PPARδ agonist 10 （5-20 mg/kg，口服，每日一次）在大鼠体内表现出良好的口服药代动力学特性[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model:
CAS	685139-10-0
Formula	C23H17Br2ClO3S
Molar Mass	568.71
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Sauerberg P, et al. Identification and synthesis of a novel selective partial PPARdelta agonist with full efficacy on lipid metabolism in vitro and in vivo. J Med Chem. 2007 Apr 5;50(7):1495-503.

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