PKN3-IN-1_product_DataBase

Bioactivity	PKN3-IN-1 (compound 16) inhibits PKN3 (serine/threonine protein kinase 3) and GAK (cyclin G-associated kinase) with IC50 of 0.014 μM and Ki of 0.0044 μM respectively. PKN3-IN-1 is a potential tool compound to study the cell biology of PKN3 and its role in pancreatic and prostate cancer and T-cell acute lymphoblastic leukemia [1].
Invitro	PKN3-IN-1 (1 μM，48 h) 在 HEK 293 细胞中抑制 PKN3，IC50 为 0.014 μM [1].PKN3-IN-1 (1 μM，24 h) 在 HEK 293 细胞中抑制 GAK，Ki 为 0.0044 μM [2].PKN3-IN-1 (1.3 μM) 在 5 μM 以下具有细胞内靶向结合能力[1]. MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> PKN3-IN-1 相关抗体:
CAS	2361545-75-5
Formula	C18H17IN2O3
Molar Mass	436.24
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Asquith CRM, et al. Identification of 4-Anilinoquin(az)oline as a Cell-Active Protein Kinase Novel 3 (PKN3) Inhibitor Chemotype. ChemMedChem. 2022 Jun 20;17(12):e202200161. [2]. Asquith CRM, et al. Identification and Optimization of 4-Anilinoquinolines as Inhibitors of Cyclin G Associated Kinase. ChemMedChem. 2018 Jan 8;13(1):48-66.

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