PKC/PKD-IN-1

CAS: 1071135-06-2 F: C23H28N6 W: 388.51

PKC/PKD-IN-1 (Compound 13C) is an orally active dual protein kinase C/D (PKC/PKD) inhibitor with an IC50 value of 0.6 nM

Contact QiTai

This product is for research use only, not for human use. We do not sell to patients.

Bioactivity	PKC/PKD-IN-1 (Compound 13C) is an orally active dual protein kinase C/D (PKC/PKD) inhibitor with an IC50 value of 0.6 nM for PKD1. PKC/PKD-IN-1 can attenuate high-salt diet-induced cardiac hypertrophy and can be used in the study of heart failure[1].
In Vivo	PKC/PKD-IN-1 (Compound 13C) (5-50 mg/kg; 口服; 一天一次连续 14 天) 在 Dahl salt-sensitive (DSS) 大鼠中，剂量为 50 mg/kg时能减轻高盐饮食诱导的心肌肥厚[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only.
CAS	1071135-06-2
Formula	C23H28N6
Molar Mass	388.51
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Meredith EL, et al. Identification of orally available naphthyridine protein kinase D inhibitors. J Med Chem. 2010;53(15):5400-5421.