| Bioactivity | PI3K/mTOR Inhibitor-9 (Compound 1) is a potent mTOR and PI3K inhibitor with IC50 values of 38 nM, 6.6 μM, 6.6 μM and 0.8 μM against mTOR (phospho-S6 cellular assay), PI3Kα, PI3Kγ and PI3Kδ, respectively[1]. |
| Invitro | PI3K/mTOR Inhibitor-9 (Compound 1) shows good selectivity over the related kinases PI3Kα, β and γ, although with lower selectivity over PI3Kδ[1].PI3K/mTOR Inhibitor-9 inhibits CYP2D6 (IC50 = 1.98 µM) and shows time-dependent inhibition (TDI) of CYP3A4 (rate of enzyme inhibition, kobs = 0.080 /min)[1].PI3K/mTOR Inhibitor-9 shows good permeability with no sign of P-gp efflux (B-A/A-B: 0.95) [1]. |
| Name | PI3K/mTOR Inhibitor-9 |
| CAS | 1392421-71-4 |
| Formula | C23H27N7O2 |
| Molar Mass | 433.51 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Bonazzi S, et al. Discovery of a Brain-Penetrant ATP-Competitive Inhibitor of the Mechanistic Target of Rapamycin (mTOR) for CNS Disorders. J Med Chem. 2020 Feb 13;63(3):1068-1083. |
PI3K/mTOR Inhibitor-9
CAS: 1392421-71-4 F: C23H27N7O2 W: 433.51
PI3K/mTOR Inhibitor-9 (Compound 1) is a potent mTOR and PI3K inhibitor with IC50 values of 38 nM, 6.6 μM, 6.6 μM and 0
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