| Bioactivity | PI3K-IN-54 (compound 10w) 是一种泛 PI3K 抑制剂。PI3K-IN-54 对 p110α、p110β、p110δ 的 IC50 值分别为 0.22 nM、1.4 nM 和 0.38 nM。PI3K-IN-54 可用于癌症研究[1]。 |
| CAS | 1336890-05-1 |
| Formula | C20H24F2N8O3 |
| Molar Mass | 462.45 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Rewcastle GW,et al. Synthesis and biological evaluation of novel analogues of the pan class I phosphatidylinositol 3-kinase (PI3K) inhibitor 2-(difluoromethyl)-1-[4,6-di(4-morpholinyl)-1,3,5-triazin-2-yl]-1H-benzimidazole (ZSTK474). J Med Chem. 2011 Oct 27;54(20):7105-26. |